My Mass Effect RPG campaign takes place in parallel to the events of ME2. The players are hot on the trail behind Cmdr
Shepard, uncovering the secrets of the Reapers and the Collectors.

I start the players all as prisoners on the Blue Sun's prison ship Purgatory (the one with Jack). Shepard's actions allow them to find a way to escape in the chaos.

(Also as the players go through the game, I like to give little hints about what game decisions Shepard has made.)